The Possible Anti-nociceptive Effect of Troxerutin and Neural Interactions Using Formalin and Writhing Tests in Mice

Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, nitrergic systems in mice. Methods: A total 340 male mice were randomly divided into 2 categories. Each category included four experiments groups. In first experiment formalin examination, animals intraperitoneally received saline (50, 150, 300 mg/kg). second experiment, saline, naloxone (2 mg/kg), (300 troxerutin+naloxone. third fourth experiments, L-NAME (L-NG-Nitroarginine methyl ester) cyproheptadine injected. this test, was injected paw licking time (pain sense) recorded. writhing experimental groups treated similarly acetic acid. Then, inhibition movements Results: According to findings, decreased pain test (P=0.001). Naloxone L-NAME+troxerutin significantly diminished effect inhibited response Conclusion: These results suggested that decreases inflammatory mice, is mediated by opioidergic systems.